Dedicated to St. Lawrence, the church is documented as early as the 6th century AD, built over theancient Roman Forum, traces of which remain especially behind theapse.
The primitive basilica was first rebuilt in the late 11th and early 12th centuries, and a Romanesque bell tower with mullioned windows with two lights was added to it .
The building appeared as a three-aisled basilica with a raised chancel.
A radical renovation of the church was carried out in 1625 by Cardinal Giulio Roma, then bishop of Tivoli.
The reconstruction, which was much criticized, involved lowering the presbyterial area; it was carried out quickly and completed with the portico in 1650.
The plan follows the typology of a single-nave sacred building with side chapels. Of the ancient basilica, the Romanesque bell tower was preserved, as well as some funerary monuments.
The most valuable works preserved inside the cathedral are the wooden Group of the Deposition (in the 4th chapel on the right), a masterpiece of Romanesque sculpture; the Triptych of the Savior (in the 3rd chapel of the left aisle), dating from the 12th century; and the silver case covering the Triptych, from the early 15th century.